Christina Applegate Misdiagnosed With MS

Christina Applegate says she was misdiagnosed with MS five years ago, leaving her confused and back at square one.

Oct 20, 2026

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Christina Applegate Misdiagnosed With MS

Christina Applegate says she was misdiagnosed with MS five years ago, leaving her confused and back at square one.

In brief

Christina Applegate says she was misdiagnosed with MS five years ago, leaving her confused and back at square one. Christina Applegate revealed she was misdiagnosed with multiple sclerosis five years ago, causing her to question her health and MS advocacy. Originally reported by BuzzFeed.

Misdiagnosis Shock

A person with long hair is speaking into a microphone, appearing emotional with tears in their eyes

Christina Applegate revealed her doctor told her she was misdiagnosed with multiple sclerosis five years ago.

“Congratulations, you don’t have MS”

Health Confusion

MRI scan of a human brain showing detailed sections of brain tissue and structures

She says she hasn’t gotten better and has worse symptoms since the misdiagnosis, questioning her health and MS advocacy.

“I haven’t gotten better, Jamie. If anything, I’ve gotten worse in some ways”

Doctor's Explanation

A medical professional examines brain scans on a tablet, focusing on detailed images with a stethoscope visible in the background

A neurology professor states nearly 20% of MS diagnoses are incorrect, with many on medication.

“Almost 1 in 5 of these people who’d been told they had MS, some for decades, didn’t actually have it”

Emotional Impact

A person with long, wavy hair, wearing elegant makeup, is seen at a formal event, smiling softly

Applegate describes negative thoughts about her health and whether she’s let people down as an MS advocate.

“Everything I was doing, I had a reason. I had a fucking reason why my days sucked every day, and now I don’t have a reason and it’s very unnerving and it’s really confusing for me”

Here's the gist

Christina Applegate revealed she was misdiagnosed with multiple sclerosis five years ago, causing her to question her health and MS advocacy.

Read the original on BuzzFeed

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