Computer model backs Lions and 49ers in Week 3

SportsLine's algorithm picks Detroit and San Francisco as its strongest Week 3 NFL bets after simulating every game 10,000 times.

Sep 23, 2026

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Computer model backs Lions and 49ers in Week 3

SportsLine's algorithm picks Detroit and San Francisco as its strongest Week 3 NFL bets after simulating every game 10,000 times.

In brief

SportsLine's algorithm picks Detroit and San Francisco as its strongest Week 3 NFL bets after simulating every game 10,000 times. The Lions cover spreads at an 80% rate after losses, while the 49ers rank top-5 in both offense and defense. Originally reported by CBS Sports.

Travel shapes Week 3 matchups

West Coast teams face early kickoffs on the East Coast, while Dallas and Baltimore play in Rio de Janeiro, Brazil for the first ever NFL Rio Game.

Computer model's track record

SportsLine's model simulates every NFL game 10,000 times and has returned over $7,000 for $100 bettors since inception. It's on a 53-41 run on top-rated picks since 2024.

Lions favored over Jets

Lions favored over Jets

Detroit is a 6.5-point favorite against New York. The Lions are 12-3 against the spread after losses since 2023, an 80% cover rate that's the best in the NFL.

“Detroit is 12-3 ATS following a loss since 2023, with that 80% cover rate the best in the NFL.”

49ers' dominant two-week start

San Francisco is an 8.5-point favorite at home against Arizona. The Niners are the only team ranking top-5 in both scoring offense and defense, and they're projected to cover the spread in over 50% of simulations.

“San Fran is forecasted to cover the spread in well over 50% of simulations as it's looked like, arguably, the best team in the league through two weeks.”

Cardinals struggling on both sides

Arizona is coming off a 24-point home loss to Seattle's backup quarterback. The Cards rank in the bottom 10 in both rushing and passing offense.

49ers projected to win big

The model forecasts San Francisco to win by double digits against Arizona. The Over is expected to hit almost 60% of the time in this matchup.

“San Francisco wins by double digits per the model, with the Over hitting almost 60% of the time.”

Five A-rated picks available

The model has identified five A-rated spread picks for Week 3 that could deliver significant payouts. Full picks for every game are available at SportsLine.

The bottom line

The Lions cover spreads at an 80% rate after losses, while the 49ers rank top-5 in both offense and defense.

Read the original on CBS Sports

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