NFL Week 3 Betting Picks 2026

SportsLine experts predict NFL Week 3 totals and spreads for Sunday's games

Sep 27, 2026

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NFL Week 3 Betting Picks 2026

SportsLine experts predict NFL Week 3 totals and spreads for Sunday's games

In brief

SportsLine experts predict NFL Week 3 totals and spreads for Sunday's games Chargers vs. Bills game likely to exceed 50.5 points Originally reported by CBS Sports.

Bills vs Chargers

SportsLine predicts over 50.5 points in Bills-Chargers game

“So far, new chargers offensive coordinator mike mcdaniel isn't flexing much”

Browns vs Panthers

Browns favored by 2.5 points in Panthers-Browns matchup

“Bryce young has carved up two bad defenses but both were zone-heavy schemes”

Colts vs Texans

Colts vs Texans

Colts favored by 1.5 points in Colts-Texans game

“Houston's offensive line is struggling with c.j. stroud facing more pressure”

Patriots vs Jaguars

Patriots favored by 3 points in Patriots-Jaguars game

“The patriots enjoyed a comfortable win against a steelers team that couldn't move the ball”

Giants vs Titans

Titans favored by 2.5 points in Giants-Titans game

“The titans averaged a healthy five point seven yards per play in their loss to philadelphia”

Seahawks vs Commanders

Seahawks favored by 7.5 points in Seahawks-Commanders game

“Drew lock has delivered strong numbers thus far with the washington defense having no answer for cee dee lamb”

Cardinals vs 49ers

Cardinals favored by 8.5 points in Cardinals-49ers game

“The forty nines started the season with a pair of blowouts while the cardinals crashed back to earth”

Vikings vs Buccaneers

Justin Jefferson over 68.5 receiving yards in Vikings-Buccaneers game

“Coming off a rain-soaked game in which the vikings hardly had the ball”

Rams vs Broncos

Rams favored by 2.5 points in Rams-Broncos game

“Aaron donald made his season debut and played thirty two snaps”

Eagles vs Bears

Eagles under 44.5 points in Eagles-Bears game

“The eagles have shown me nothing through two weeks on offense with three hundred and eighteen and three hundred and forty one yards”

The short version

Chargers vs. Bills game likely to exceed 50.5 points

Read the original on CBS Sports

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