NFL Week 5 Picks

SportsLine experts predict NFL Week 5 odds and prop bets for Sunday, Oct. 11.

Oct 10, 2026

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NFL Week 5 Picks

SportsLine experts predict NFL Week 5 odds and prop bets for Sunday, Oct. 11.

In brief

SportsLine experts predict NFL Week 5 odds and prop bets for Sunday, Oct. 11. SportsLine experts provide NFL Week 5 betting picks and prop bets for Sunday, Oct. 11 games. Originally reported by CBS Sports.

Week 5 NFL Schedule

The Week 5 NFL schedule features top contests including Bears vs. Packers, 49ers vs. Seahawks, and Ravens vs. Falcons.

Week 5 NFL Odds

The Bears are 2.5-point favorites against the Packers, and the Rams are 3-point favorites against the Bills with an over/under of 54.5 points.

Eagles vs. Jaguars

Eagles vs. Jaguars

Eagles Under 17.5 total team points with R.J. White citing injuries and travel challenges.

“This spread has ballooned since it opened, with people fading a severely injured Eagles team”

Bears vs. Packers

Bears (-2.5) with David Bearman highlighting their strong defense and time of possession.

“It doesn't seem to matter who the qb is in chicago, as the bears still lead the nfl in total yards”

Texans vs. Titans

Titans (+7.5) with Jeff Hochman noting their offensive line and weather conditions.

“Tennessee's offensive line has allowed only six sacks, tying for the sixth fewest”

Raiders vs. Patriots

Raiders (+3.5) with R.J. White analyzing their recent performance and rivalry dynamics.

“The raiders saw a significant rise in quality of opponent in week four and largely rose to the challenge”

Giants vs. Commanders

Cam Skattebo Under 77.5 total rushing + receiving yards with Alex Selesnick noting his struggles.

“Cam Skattebo and the Giants' rushing attack have been largely ineffective this season”

Vikings vs. Saints

Under 42.5 total points with R.J. White emphasizing the Vikings' defense.

“The vikings are perhaps the biggest surprise through four weeks at 4 point zero”

Browns vs. Jets

Quinshon Judkins Over 15.5 total carries with Larry Hartstein highlighting his performance.

“The browns have handed the ball to a running back 67 times”

Colts vs. Steelers

David Jones Under 219.5 total passing yards with R.J. White analyzing their strategy.

“The colts went into their london game with a baffling game plan: establish the pass”

Broncos at Chargers

Omarion Hampton Over 37.5 total rushing yards with Alex Selesnick noting his potential.

“This looks like a nice buy low for omarion hampton, who has not lived up to expectations for a struggling chargers team”

Lions at Cardinals

Michael Wilson Over 5.5 total receptions with Prop Bet Guy Doug highlighting his performance.

“Michael wilson has notched 30 targets over the last two games with a wild 42 point six percent first read rate”

49ers vs. Seahawks

Seahawks (-2.5) with R.J. White noting their strong defense.

“The forty nines are, by some accounts, the best team in the league, with a top three unit on both sides of the ball”

Ravens vs. Falcons

Falcons (-2.5) with Mike Tierney highlighting their recent performance.

“The falcons are back in primetime, right where they like it”

Bills vs. Rams

Kyren Williams Over 89.5 total rushing + receiving yards with Alex Selesnick analyzing their strategy.

“Kyren williams has been awesome for a struggling rams team and despite the team sputtering a bit”

In short

SportsLine experts provide NFL Week 5 betting picks and prop bets for Sunday, Oct. 11 games.

Read the original on CBS Sports

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