Week 3 NFL odds, picks and predictions

Buffalo stays unbeaten against LA, while injury questions cloud Giants-Titans and Commanders-Seahawks.

Sep 25, 2026

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Week 3 NFL odds, picks and predictions

Buffalo stays unbeaten against LA, while injury questions cloud Giants-Titans and Commanders-Seahawks.

In brief

Buffalo stays unbeaten against LA, while injury questions cloud Giants-Titans and Commanders-Seahawks. Week 3 separates early contenders from pretenders, with unbeaten teams like Buffalo and Cincinnati facing stiffer tests while injured quarterbacks could reshape playoff races. Originally reported by CBS Sports.

Buffalo stays unbeaten

The Bills opened 2-0 with Josh Allen throwing five touchdowns against Detroit and James Cook rushing for 135 yards in a 41-31 win. They face the 0-2 Chargers as seven-point home favorites.

Carolina's stunning turnaround

The Panthers allowed 59 points in Week 1 but crushed Atlanta 34-3 in Week 2 with Bryce Young throwing three touchdown passes. They travel to Cleveland as three-point road favorites.

Detroit's heartbreak continues

Detroit's heartbreak continues

The Lions scored 31 points at Buffalo but lost, with Jared Goff throwing four touchdown passes. They host the Jets at home favored by 6.5 points.

Houston's offense stalls

The Texans produced 374 yards against Cincinnati but scored only six points and failed to reach the end zone in Week 2. They host the Colts as 2.5-point favorites despite offensive struggles.

Kansas City's perfect start

Patrick Mahomes led the Chiefs to a 33-30 overtime win over Indianapolis to improve to 2-0. They face the struggling Dolphins as 10.5-point favorites, the largest spread of Sunday's early games.

Giants face Titans uncertainty

Jaxson Dart suffered a potentially season-ending knee injury, forcing the Giants to turn to Jameis Winston. New York is favored by 2.5 points at home against Tennessee.

Cincinnati's dominant defense

The Bengals held Houston to six points in a 20-6 Week 2 win, with Joe Burrow and Ja'Marr Chase connecting for two touchdowns. They travel to Pittsburgh as 3.5-point favorites.

Seahawks defense dominates

Seattle crushed Arizona 31-7 with Jaxon Smith-Njigba catching three touchdown passes from Drew Lock. The Seahawks hold a strong defense heading into a road matchup against Washington.

Daniels' elbow injury clouds Commanders

Jayden Daniels suffered a dislocated left elbow in a 37-20 loss to Dallas, leaving Marcus Mariota as the backup. Washington faces Seattle's strong defense as 6.5-point underdogs.

Darnold on track to return

Seahawks quarterback Sam Darnold is on a good track to return from a glute injury, per head coach Mike Macdonald. Seattle is favored by 7.5 points on the road against Washington.

“on a good track to return”

Patriots' defensive statement

New England held Pittsburgh to three points in Week 2 with TreVeyon Henderson scoring on a 39-yard touchdown run. Jacksonville heads home as 2.5-point favorites after stalling offensively.

San Francisco's hot start

The 49ers improved to 2-0 with Brock Purdy completing 20 of 22 passes for 287 yards and two touchdowns against Miami. They face the struggling Cardinals as 8.5-point favorites.

Arizona's offensive collapse

Seattle held the Cardinals to 151 total yards in a 31-7 defeat, with Jacoby Brissett throwing for only 95 yards. Arizona faces a rolling 49ers team in Week 3.

Minnesota's defensive grind

The Vikings beat Chicago 9-3 with Aaron Jones rushing for 105 yards and Brian Flores' defense keeping the Bears out of the end zone. Minnesota travels to Tampa Bay as 2.5-point favorites.

Dallas' explosive offense

Dak Prescott threw four touchdown passes and became Dallas' franchise leader in career passing scores, with CeeDee Lamb adding 153 receiving yards and two touchdowns in a 37-20 win. The Cowboys face Baltimore in Brazil.

New Orleans' shocking upset

The Saints won 24-17 at Baltimore with Tyler Shough completing 27 of 34 passes for 252 yards. They host the 2-0 Raiders as three-point favorites in their home opener.

Denver's comeback win

Bo Nix threw for 288 yards and Jaylen Waddle caught 138 receiving yards as the Broncos erased a 10-point deficit to beat Jacksonville 20-13. Denver hosts the Rams as 2.5-point underdogs.

Williams' hamstring concern

Caleb Williams left Chicago's 9-3 loss to Minnesota in the fourth quarter with a right hamstring injury, forcing Tyson Bagent into the game. The Bears face the unbeaten Eagles on Monday night.

Philadelphia's survival mode

The Eagles escaped Tennessee 24-20 with Jalen Hurts throwing for 264 yards and two touchdowns, and DeVonta Smith catching 10 passes for 117 yards. Philadelphia is favored by 4.5 points at Chicago on Monday.

At a glance

Week 3 separates early contenders from pretenders, with unbeaten teams like Buffalo and Cincinnati facing stiffer tests while injured quarterbacks could reshape playoff races.

Read the original on CBS Sports

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