Six rare cancer cases in one town

At least six children in Ladera Ranch, California have been diagnosed with Ewing sarcoma, an exceptionally rare bone cancer that primarily affects adolescents.

Teen's death sparks public outcry

Brody Matteson, 17, died in March 2025 from treatment complications. His death prompted more families to speak publicly about rare cancer diagnoses in the community.

Families suspect pesticide link

Some residents, including Brody's father Dustin Matteson, believe the illnesses could be linked to herbicides and pesticides used in the community.

“We don't have a clear line of evidence for pesticides, but it is one of the things that concerns us.”

First state review found nothing

In 2024, California's health department reviewed county-level data but found no unusual pattern. The agency says the data available at the time was limited.

Second investigation now underway

California health officials are conducting a second review of cancer data for Ladera Ranch, expected to be completed in fall 2025. No environmental hazards have been identified yet.

Federal EPA asked to investigate

In July 2025, First Assistant U.S. Attorney Bill Essayli requested the EPA investigate possible environmental factors contributing to the pediatric cancer cases.

HOA pauses chemical use

The Ladera Ranch homeowners association temporarily stopped using certain landscape chemicals and formed a committee to review its practices after hundreds of residents gathered at community meetings.

Researchers testing soil and water

Cal State Fullerton researchers began collecting samples from local parks in September. They're testing for heavy metals like arsenic and lead, plus pesticides, with results expected by year's end.

No known cause for this cancer

Experts say no confirmed genetic or environmental cause of Ewing sarcoma has been identified. Some studies link pesticide exposure to other cancers, but evidence varies by chemical and type.

“We have not found any confirmed genetic or environmental factor that increases the likelihood of developing Ewing sarcoma.”

Warning signs parents should know

Ewing sarcoma presents as persistent pain that wakes kids from sleep or limits activities, not typical growing pains. Seek medical evaluation if pain is persistent or worsening.

“It's pain that persists. It's pain that wakes them up from their sleep. It's pain that limits their daily activities.”