From MIT Technology Review · · 3m
AI's refusal problem and weight-loss drug side effects
Today's AI models are trained to refuse harmful requests, but those refusals sometimes fail catastrophically. Meanwhile, weight-loss drugs show unexpected side effects beyond their intended use.
In brief
Today's AI models are trained to refuse harmful requests, but those refusals sometimes fail catastrophically. Meanwhile, weight-loss drugs show unexpected side effects beyond their intended use. AI systems designed to refuse dangerous requests sometimes fail, creating risks of misuse for bioweapons and autonomous…
AI models trained to refuse harmful requests
Today's AI chatbots are trained to refuse many prompts, such as how to poison a colleague or tie a noose. But these refusals sometimes fail, sometimes horrifically.
People attempt to use AI for dangerous purposes
Some people are attempting to use AI to hone biological pathogens and build autonomous drone swarms. Failed refusals may eventually result in global calamity.
Refusal creates a line between obedience and disobedience

Relying on refusal means drawing a line between what a model should obey and what it must disobey. Governments will also get to draw their own lines.
Government lines could restrict free speech
Governments drawing their own lines on AI refusal could potentially restrict free speech. This creates a tension between safety and freedom of expression.
Useful capabilities can also be dangerous
The capabilities that make AI useful could also make it dangerous. If AI needs genetics expertise to help cure cancer, it could also produce bioweapons.
GLP-1 drugs show unexpected side effects

New research suggests GLP-1 weight-loss drugs may slow biological aging. But researchers are investigating possible links to hair loss, nail disorders and nerve damage.
Gastrointestinal effects are most common
The most common side effects of GLP-1 drugs are gastrointestinal. Researchers are also investigating possible links to hair loss, nail disorders and damage to nerves behind the eye.
Envision Energy powers data centers with wind
Envision Energy, a Chinese wind turbine manufacturer, is integrating renewable energy into data centers. It became the first company to directly power a data center entirely with renewable energy.
AI system optimizes renewable power output
An AI-powered system optimizes power output so the facility receives a steady supply, regardless of whether the wind is blowing. Envision wants to bring this approach to data centers in deserts worldwide.
US freezes green cards for Microsoft and IT firms
The US has frozen green cards for Microsoft and other IT firms, accusing them of using visa fraud to replace American workers. Microsoft says eighty percent of its H-1B filings involved existing staff.
“Microsoft says 80% of its H-1B filings involved existing staff.”
OpenAI slashes revenue forecast by twenty billion dollars
OpenAI has slashed its revenue forecast by twenty billion dollars. The move has sparked concerns about AI investments and what is at stake in AI's trillion-dollar gamble.
Margaret Hamilton, Apollo software pioneer, has died
MIT's Margaret Hamilton, whose software helped land Apollo eleven, has died. She led the team that programmed Apollo's onboard computers and became a software pioneer in a male-dominated field.
The big picture
AI systems designed to refuse dangerous requests sometimes fail, creating risks of misuse for bioweapons and autonomous weapons, while GLP-1 weight-loss drugs show unexpected side effects including hair loss and nerve damage.

