From NBC Sports · · 2m
49ers vs. Cowboys Prediction
49ers lead Cowboys in Super Bowl contention with key QB matchup and injury updates.
In brief
49ers lead Cowboys in Super Bowl contention with key QB matchup and injury updates. San Francisco 49ers (7-1) face Dallas Cowboys (4-5) in an NFL game with 49ers favored by 4.5 points and key injuries impacting both teams. Originally reported by NBC Sports.
Rivalry History
The 49ers and Cowboys have a storied NFL rivalry with 21-19-1 all-time series lead and four consecutive wins.
“The 49ers currently own the upper hand, leading the all-time series 21-19-1 and having won the past four meetings.”
Current Standings
San Francisco 49ers (7-1) face Dallas Cowboys (4-5) in an NFL matchup with contrasting point averages.
“The 49ers are averaging 29.4 points per game while allowing 19.5, compared with 27.3 scored and 26.2 allowed by the Cowboys.”
Recent Game Results
49ers defeated Las Vegas Raiders 38-17 with 414 total yards and 190 rushing yards.
“San Francisco led 21-10 at halftime before Jaden Dugger returned an interception 35 yards for a touchdown on the Raiders’ first offensive play of the third quarter.”
Cowboys' Recent Game
Cowboys beat Indianapolis Colts 27-23 with 508 yards of offense and 195 yards from CeeDee Lamb.
“Dak Prescott immediately answered with a 46-yard completion to Ryan Flournoy, and Javonte Williams scored from one yard out with 1:08 remaining to put Dallas ahead for good.”
Odds and Betting Trends
49ers -4.5 spread with San Francisco favored at -218 and Cowboys at +180 on DraftKings odds.
“Moneyline: San Francisco 49ers (-218), Dallas Cowboys (+180)”
Defensive Matchup
49ers rank 2nd in defensive DVOA (33.2%) and 2nd in point differential (+79.0) while Cowboys rank 29th in defensive DVOA (15.0%).
“San Francisco ranks 2nd in total DVOA (33.2%), 2nd in point differential (+79.0), 2nd in yards allowed (315.62 per game), 2nd in yards per play allowed (5.16), 1st in yards per carry allowed (3.34), 2nd in yards per reception allowed (9.99), and 6th in points allowed (19.5 per game).”
QB Matchup
Brock Purdy (49ers) and Dak Prescott (Cowboys) have contrasting stats with Purdy at 109.8 RTG and Prescott at 95.3 RTG.
“49ers: Brock Purdy, 2026 Statistics: 8GP, 1980 Passing Yards, 17 TDs, 5 INTs, 109.8 RTG, Sacked 8 times”
Top Playmakers
49ers' Christian McCaffrey and Cowboys' Javonte Williams lead the scoring with 9 TDs and 9 TDs respectively.
“49ers: Christian McCaffrey, 2026 Statistics: 8GP, 102 carries for 457 Yds, 9 TDs / 36 receptions on 45 targets for 270 Yds, 1 TD”
Injury Update
49ers have WR Mike Evans (Achilles) and WR Deebo Samuel Sr. (hamstring) listed as questionable for Sunday’s game.
“WR Mike Evans (Achilles) is listed as questionable for Sunday’s game”
Cowboys Injury Update
Cowboys have RB Tyler Goodson (knee) ruled out and WR KaVontae Turpin (ribs) listed as questionable for Sunday’s game.
“RB Tyler Goodson (knee) has been ruled OUT of Sunday’s game”
Betting Trends
49ers are 5-3 against the spread this season while Cowboys are 4-5 against the spread.
“The 49ers are 5-3 against the spread this season”
Player Prop
Javonte Williams Anytime Touchdown prop has a 0.88 touchdown projection with 77.78% season mark at 1.11 per game.
“His projection sits at 0.88 touchdowns”
Game Details
Game on Sunday, November 15, 2026 at 4:25 PM at AT&T Stadium in Arlington, TX on FOX.
“Date: Sunday, November 15, 2026”
Expert Picks
NBC Sports recommends 49ers -4.5 spread and Game Total UNDER 55.5.
“NBC Sports is recommending a play on the 49ers -4.5”
In short
San Francisco 49ers (7-1) face Dallas Cowboys (4-5) in an NFL game with 49ers favored by 4.5 points and key injuries impacting both teams.
