From Newsweek · · 1m 10s
DNA Pattern Linked to Higher Alzheimer’s Odds
Study finds DNA repeats may increase Alzheimer’s risk, especially in Chinese populations.
In brief
Study finds DNA repeats may increase Alzheimer’s risk, especially in Chinese populations. A DNA sequence repeat in the FAM193B gene doubles Alzheimer’s odds for those with 18+ repeats compared to 11 or fewer. Originally reported by Newsweek.
Study Finds DNA Pattern
Researchers discovered a DNA sequence repeat in the FAM193B gene may increase Alzheimer’s disease risk.
Higher Odds in Chinese Cohort
Chinese participants with 18+ CCG repeats had twice the odds of Alzheimer’s compared to those with 11 or fewer repeats.
Weaker Link in Europeans
European participants showed a weaker association with the same DNA pattern, though it was still identified.
Published in Nature Neuroscience
The study was published in Nature Neuroscience on October 12, 2026.
FAM193B Expression Impact
More CCG repeats increased FAM193B expression, leading to nerve cell DNA damage and cellular harm.
Enzyme Interaction
FAM193B protein interacts with enzymes GSK3alpha and GSK3beta, linked to Alzheimer’s proteins.
Clinical Applications
The finding could improve Alzheimer’s risk prediction in clinical settings with ancestral-specific considerations.
Need for Further Research
Larger studies and functional research are needed to confirm the gene’s role in Alzheimer’s disease.
The headline
A DNA sequence repeat in the FAM193B gene doubles Alzheimer’s odds for those with 18+ repeats compared to 11 or fewer.
