Newsweek

Hormone Therapy Boosts GLP-1 Weight Loss for Some Women

Estrogen may enhance weight loss from GLP-1 drugs for women going through menopause.

Nov 3, 2026

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Hormone Therapy Boosts GLP-1 Weight Loss for Some Women

Estrogen may enhance weight loss from GLP-1 drugs for women going through menopause.

In brief

Estrogen may enhance weight loss from GLP-1 drugs for women going through menopause. Women using hormone therapy lost 11.6% more weight with GLP-1 drugs like Ozempic than those without therapy. Originally reported by Newsweek.

Menopause and Weight Loss

Menopause makes weight loss harder for women, especially as more turn to GLP-1 drugs like Ozempic and Wegovy.

Study Finds Estrogen Role

A Mayo Clinic Florida study suggests estrogen affects how some women respond to GLP-1 weight loss drugs.

Semaglutide Group Results

Semaglutide Group Results

Women on semaglutide lost 11.6% more weight with hormone therapy by 15 months compared to nonusers.

Tirzepatide Group Results

Hormone therapy users lost slightly more weight early with tirzepatide but differences were not statistically significant later.

Lead Author Explanation

Dr. Regina Castaneda says estrogen may amplify GLP-1's appetite-suppressing effects through synergy.

Expert Opinion

A woman holds a pen injection for diabetics and lowering blood sugar.

Dr. Jessica Duncan says hormone therapy may help weight loss for midlife women but needs more research.

The headline

Women using hormone therapy lost 11.6% more weight with GLP-1 drugs like Ozempic than those without therapy.

Read the original on Newsweek

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