Why Christina Applegate Was Misdiagnosed With MS

Christina Applegate reveals she was misdiagnosed with multiple sclerosis after years of treatment.

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Oct 20, 2026

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Why Christina Applegate Was Misdiagnosed With MS

Christina Applegate reveals she was misdiagnosed with multiple sclerosis after years of treatment.

In brief

Christina Applegate reveals she was misdiagnosed with multiple sclerosis after years of treatment. Christina Applegate was misdiagnosed with multiple sclerosis, now working with doctors to find the real cause of her symptoms. Originally reported by Rolling Stone.

Christina Applegate's Misdiagnosis

Christina Applegate at the 29th Annual Screen Actors Guild Awards held at the Fairmont Century Plaza on February 26, 2023 in Los Angeles, California. (Photo by

Christina Applegate revealed she was misdiagnosed with multiple sclerosis after five years of treatment.

“She came into my room and said, 'Congratulations, you don’t have MS'”

Seven-Month Break for Processing

Applegate took a seven-month break to process the diagnosis after receiving it from her doctor.

Misdiagnosis Prevalence

A 2019 study found 20 percent of MS patients were misdiagnosed, with some studies showing up to 67 percent.

Radiologic Isolated Syndrome

Radiologic Isolated Syndrome

Some patients have no symptoms but show MS-like brain MRI results, called radiologic isolated syndrome.

2024 Diagnostic Criteria

Newer MS diagnostic criteria from 2024 include more tests to improve accuracy over older methods.

Why Misdiagnoses Happen

Lack of a definitive MS biomarker and overlapping symptoms with other diseases cause frequent misdiagnoses.

Treatment Risks

Patients without MS may take unnecessary immune-suppressing medications for MS.

Financial Burden

MS treatment costs include medications, blood tests, and time off work, creating a significant financial burden.

Here's the gist

Christina Applegate was misdiagnosed with multiple sclerosis, now working with doctors to find the real cause of her symptoms.

Read the original on Rolling Stone

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