# 49ers vs. Cowboys Prediction > 49ers lead Cowboys in Super Bowl contention with key QB matchup and injury updates. - Title: 49ers vs. Cowboys Prediction · NBC Sports | Shortify - Summary: 49ers lead Cowboys in Super Bowl contention with key QB matchup and injury updates. - Keywords: 49ers, cowboys, nfl, brock purdy, dak prescott, injury update, betting trends, qb matchup, odds, game stats, NBC Sports - Source: NBC Sports — https://nbcsports.com/nfl/news/49ers-vs-cowboys-prediction-odds-expert-picks-qb-matchup-injury-update-betting-trends-and-stats - Published: 2026-11-10T18:20:51.874+00:00 - Read time: 1 min - Topics: 49ers, cowboys, nfl, brock purdy, dak prescott, injury update, betting trends, qb matchup, odds, game stats, sports ## Rivalry History The 49ers and Cowboys have a storied NFL rivalry with 21-19-1 all-time series lead and four consecutive wins. > The 49ers currently own the upper hand, leading the all-time series 21-19-1 and having won the past four meetings. ## Current Standings San Francisco 49ers (7-1) face Dallas Cowboys (4-5) in an NFL matchup with contrasting point averages. > The 49ers are averaging 29.4 points per game while allowing 19.5, compared with 27.3 scored and 26.2 allowed by the Cowboys. ## Recent Game Results 49ers defeated Las Vegas Raiders 38-17 with 414 total yards and 190 rushing yards. > San Francisco led 21-10 at halftime before Jaden Dugger returned an interception 35 yards for a touchdown on the Raiders’ first offensive play of the third quarter. ## Cowboys' Recent Game Cowboys beat Indianapolis Colts 27-23 with 508 yards of offense and 195 yards from CeeDee Lamb. > Dak Prescott immediately answered with a 46-yard completion to Ryan Flournoy, and Javonte Williams scored from one yard out with 1:08 remaining to put Dallas ahead for good. ## Odds and Betting Trends 49ers -4.5 spread with San Francisco favored at -218 and Cowboys at +180 on DraftKings odds. > Moneyline: San Francisco 49ers (-218), Dallas Cowboys (+180) ## Defensive Matchup 49ers rank 2nd in defensive DVOA (33.2%) and 2nd in point differential (+79.0) while Cowboys rank 29th in defensive DVOA (15.0%). > San Francisco ranks 2nd in total DVOA (33.2%), 2nd in point differential (+79.0), 2nd in yards allowed (315.62 per game), 2nd in yards per play allowed (5.16), 1st in yards per carry allowed (3.34), 2nd in yards per reception allowed (9.99), and 6th in points allowed (19.5 per game). ## QB Matchup Brock Purdy (49ers) and Dak Prescott (Cowboys) have contrasting stats with Purdy at 109.8 RTG and Prescott at 95.3 RTG. > 49ers: Brock Purdy, 2026 Statistics: 8GP, 1980 Passing Yards, 17 TDs, 5 INTs, 109.8 RTG, Sacked 8 times ## Top Playmakers 49ers' Christian McCaffrey and Cowboys' Javonte Williams lead the scoring with 9 TDs and 9 TDs respectively. > 49ers: Christian McCaffrey, 2026 Statistics: 8GP, 102 carries for 457 Yds, 9 TDs / 36 receptions on 45 targets for 270 Yds, 1 TD ## Injury Update 49ers have WR Mike Evans (Achilles) and WR Deebo Samuel Sr. (hamstring) listed as questionable for Sunday’s game. > WR Mike Evans (Achilles) is listed as questionable for Sunday’s game ## Cowboys Injury Update Cowboys have RB Tyler Goodson (knee) ruled out and WR KaVontae Turpin (ribs) listed as questionable for Sunday’s game. > RB Tyler Goodson (knee) has been ruled OUT of Sunday’s game ## Betting Trends 49ers are 5-3 against the spread this season while Cowboys are 4-5 against the spread. > The 49ers are 5-3 against the spread this season ## Player Prop Javonte Williams Anytime Touchdown prop has a 0.88 touchdown projection with 77.78% season mark at 1.11 per game. > His projection sits at 0.88 touchdowns ## Game Details Game on Sunday, November 15, 2026 at 4:25 PM at AT&T Stadium in Arlington, TX on FOX. > Date: Sunday, November 15, 2026 ## Expert Picks NBC Sports recommends 49ers -4.5 spread and Game Total UNDER 55.5. > NBC Sports is recommending a play on the 49ers -4.5 ## Key takeaway San Francisco 49ers (7-1) face Dallas Cowboys (4-5) in an NFL game with 49ers favored by 4.5 points and key injuries impacting both teams.