# 49ers vs. Seahawks: 5 predictions

> 49ers and Seahawks face Week 5 rematch with key stats and player impacts.
- Title: 49ers vs. Seahawks: 5 predictions · The San Francisco Standard
- Summary: 49ers and Seahawks face Week 5 rematch with key stats and player impacts. The 49ers and Seahawks will play in Week 5 with the 49ers favored to win 20-19…
- Keywords: 49ers, seahawks, kyle shanahan, brock purdy, george kittle, nfl, week 5, news, local, predictions, The San Francisco Standard
- Source: The San Francisco Standard — https://sfstandard.com/2026/10/09/49ers-seahawks-predictions-score-result-analysis
- Published: 2026-10-09T13:00:00+00:00
- Read time: 1 min
- Topics: 49ers, seahawks, kyle shanahan, brock purdy, george kittle, nfl, week 5, news, local
## 49ers vs. Seahawks rematch
The 49ers and Seahawks face a Week 5 rematch after Seattle knocked San Francisco out of the playoffs.
## 49ers' playoff loss impact
A 41-6 playoff loss to the Seahawks in January left a lasting impression on the 49ers.
## George Kittle's injury
Tight end George Kittle ruptured his Achilles tendon in a wild-card win over the Eagles and missed the rematch.
## Kittle's quote
The atmosphere in Seattle is one of my favorite places ever because of how much they hate us.

> The atmosphere in Seattle is one of my favorite places ever because of how much they hate us.
## Offensive star predictions
Kawakami predicts Kaelon Black as the 49ers' offensive star, while Lombardi favors Brock Purdy.
## Defensive star predictions
Kawakami names Dre Greenlaw as the defensive star, while Lombardi picks Fred Warner.
## Key stat to track
Kawakami focuses on Purdy TD passes, while Lombardi tracks Seattle’s rushing output.
## Game prediction
Kawakami predicts Seahawks 20, 49ers 17, while Lombardi forecasts 49ers 20, Seahawks 19.
## Second prediction
This will be the first of three 49ers-Seahawks games this season.
## Key takeaway

The 49ers and Seahawks will play in Week 5 with the 49ers favored to win 20-19 after a 41-6 playoff loss last season.