# Applegate discovers five-year MS diagnosis was wrong

> Christina Applegate learned she does not have multiple sclerosis after living with the diagnosis for five years, leaving her back at square one about her actual condition.
- Title: Applegate discovers five-year MS diagnosis was wrong
- Summary: Christina Applegate learned she does not have multiple sclerosis after living with the diagnosis for five years, leaving her back at square one about her…
- Keywords: christina applegate, multiple sclerosis, misdiagnosis, health, actress, news, world, Applegate, discovers, five-year, diagnosis, wrong
- Source: BBC News — https://bbc.co.uk/news/articles/cqlyel3wnxmxo
- Published: 2026-10-20T15:16:38.3+00:00
- Read time: 1 min
- Topics: christina applegate, multiple sclerosis, misdiagnosis, health, actress, news, world
## Five years living with wrong diagnosis
Christina Applegate, known for Anchorman and Married With Children, believed she had multiple sclerosis for five years before discovering the diagnosis was incorrect.
## How doctors found the mistake
A few years ago, her doctor suggested stopping her MS infusion treatment to see how her body reacted.During the time off, her body did not respond in a way that would indicate she had MS.
## Applegate's reaction to the news
Applegate said she was not happy at all about the news and in tears when she found out.She told her podcast audience, "You don't get misdiagnosed and then all of the sudden I'm better.

> You don't get misdiagnosed and then all of the sudden I'm better. If anything, I've gotten worse.
## Why MS misdiagnoses happen
About fifteen to twenty percent of patients diagnosed with MS do not actually have the disease, research suggests.
## Other conditions mimic MS symptoms
White matter spots found on MRI scans can indicate different health problems including migraines, high blood pressure, high blood sugar, high cholesterol, or vitamin B twelve deficiency, which can cause neurological problems that closely mirror…
## Applegate begins investigation next week
Applegate said she is back at square one where she does not know what is going on with her.

> I'm back at square one where I don't know what's going on with me.
## Key takeaway

Christina Applegate discovered her five-year multiple sclerosis diagnosis was wrong after doctors stopped her infusion treatment and found her body did not respond as MS patients would.