# Cardinals vs. Seahawks: Key Matchup

> Seahawks face Cardinals with Drew Lock starting after Darnold's injury.
- Title: Cardinals vs. Seahawks: Key Matchup · NBC Sports | Shortify
- Summary: Seahawks face Cardinals with Drew Lock starting after Darnold's injury. Seattle's Drew Lock starts for the Seahawks against Arizona's Gardner Minshew in a…
- Keywords: arizona cardinals, seattle seahawks, nfl, drew lock, gardner minshew, sam darnold, injury update, betting trends, qb matchup, odds, seahawks, cardinals
- Source: NBC Sports — https://nbcsports.com/nfl/news/cardinals-vs-seahawks-prediction-odds-expert-picks-qb-matchup-injury-update-betting-trends-and-stats
- Published: 2026-11-06T16:34:43.833+00:00
- Read time: 1 min
- Topics: arizona cardinals, seattle seahawks, nfl, drew lock, gardner minshew, sam darnold, injury update, betting trends, qb matchup, odds, seahawks, cardinals
## Game Details
Cardinals (3-5) and Seahawks (4-4) meet Sunday at Lumen Field in Seattle.
## Seahawks' QB Situation
Sam Darnold (quad/rib) ruled out; Drew Lock starts but with elbow injury concerns.
## Cardinals' QB Change
Gardner Minshew replaces Jacoby Brissett after Dallas overtime win.
## Seahawks' Recent Performance
Seahawks lost three of last four games, trailing 49ers by three in NFC West.
## Seahawks' Defense
Seahawks rank 1st in defensive DVOA (-24.7%), yards allowed, and third-down conversion rate.
## Cardinals' Recent Game
Cardinals rallied from 17-3 down to overtime win against Dallas with Minshew's performance.
## Historical Matchup
Seahawks lead all-time series 32-22-1 with 10 consecutive wins including 31-7 victory.
## Betting Trends
Cardinals +8.5 spread and Game Total UNDER 39.5 are NBC Sports' top bets.
## Injury Update
Cardinals have multiple players questionable including Bam Knight (concussion) and Michael Wilson (ribs).
## Seahawks' Injury Concerns
Seahawks have 12 players listed as questionable including Drew Lock (elbow) and Sam Darnold (quad).
## QB Matchup
Gardner Minshew (188 yards, 3 TDs) vs. Drew Lock (422 yards, 4 TDs) in critical game.
## Seahawks' Defense Impact
Seahawks' defense limits Cardinals' third-down conversion rate to 39.02%.
## Cardinals' Running Game
Cardinals run 69.62 plays per game with 147 yards on 11 carries from Tyler Allgeier.
## Game Odds
Cardinals (+350) vs. Seahawks (-455) with Seahawks -8.5 spread and 39.5 total.
## Key takeaway

Seattle's Drew Lock starts for the Seahawks against Arizona's Gardner Minshew in a game with significant injury impacts.