# Christina Applegate Misdiagnosed With MS

> Christina Applegate reveals she was misdiagnosed with multiple sclerosis after years of symptoms.
- Title: Christina Applegate Misdiagnosed With MS · E! Online
- Summary: Christina Applegate reveals she was misdiagnosed with multiple sclerosis after years of symptoms. Christina Applegate was misdiagnosed with MS five years ago…
- Keywords: christina applegate, multiple sclerosis, misdiagnosis, symptoms, physical therapy, infusions, b cells, neurologist, wheelchair, incontinence, fatigue, Christina
- Source: E! Online — https://eonline.com/news/1437278/christina-applegate-shares-whats-next-after-ms-misdiagnosis
- Published: 2026-10-20T17:11:00+00:00
- Read time: 1 min
- Topics: christina applegate, ms, multiple sclerosis, misdiagnosis, symptoms, physical therapy, infusions, b cells, neurologist, wheelchair, incontinence, fatigue
## Misdiagnosis Confirmed
Christina Applegate shares she was misdiagnosed with multiple sclerosis five years ago.

> I’m sure people are saying, ‘Crybaby, you don’t have MS. You know, that’s a good thing,’”
## Symptoms Started in 2021
Applegate first experienced numbness in her toes and legs in January 2021.
## Initial Diagnosis
Her doctor initially said her symptoms weren’t showing signs of MS.
## Revised Diagnosis
After additional testing, Applegate received an MS diagnosis with 40 brain lesions.

> Then finally came that day of the diagnosis when he said 'I’m so sorry,' and showed me the lesions on my brain, that were many, almost 40
## Treatment and Symptoms
Applegate underwent infusions for years but her symptoms worsened over time.
## Misdiagnosis Revisited
Her doctor later said she didn’t have MS, but Applegate’s symptoms haven’t improved.

> I was not happy at all, everybody else was so happy.
## Physical Impact
Applegate uses wheelchairs to access doctor’s offices and can’t walk from her car.
## Mental Health Strain
Applegate has experienced severe depression and lost her job due to her condition.

> I get really emotional because it stopped my life.
## Ongoing Investigation
Applegate and her medical team are starting an investigation into her symptoms.

> I’m back at square one that I don’t know what’s going on with me.
## Health Journey
Applegate has been hospitalized 30 times for MS-related symptoms.

> I've been in the hospital upwards of 30 times from throwing up and diarrhea and pain
## Family Impact
Applegate’s daughter Sadie Grace LeNoble has been affected by her condition.

> It was like losing the mom she had to this f, king thing.
## Humor as Coping
Applegate uses humor to cope with her condition and shares her struggles openly.

> I make these jokes because if I don't, I'll suffocate.
## Misdiagnosis Confirmed
Applegate was misdiagnosed with MS five years ago and now faces a new investigation.

> She came into my room and said, 'Congratulations, you don't have MS'
## Next Steps
Applegate and her medical team are starting an investigation into what could be causing her symptoms.

> I’m back at square one where I don't know what’s going on with me.
## Physical Therapy
Applegate continues physical therapy three times a week to manage her symptoms.
## Long-Term Struggle
Applegate has been living with MS for over five years and her condition continues to worsen.

> I haven't gotten better, if anything, I've gotten worse.
## Key takeaway

Christina Applegate was misdiagnosed with MS five years ago and now faces a new investigation into her symptoms.