# Christina Applegate's MS Misdiagnosis Reveal

> Christina Applegate says she doesn't have MS after years of symptoms and misdiagnosis.
- Title: Christina Applegate's MS Misdiagnosis Reveal · New York Post
- Summary: Christina Applegate says she doesn't have MS after years of symptoms and misdiagnosis. Christina Applegate's doctors confirmed she doesn't have multiple…
- Keywords: christina applegate, multiple sclerosis, ms misdiagnosis, emmy awards, neuroimmunologist, rheumatoid arthritis, spinal fluid, central nervous system, news, entertainment, Christina, Applegate's
- Source: New York Post — https://nypost.com/2026/10/20/health/christina-applegates-next-steps-after-multiple-sclerosis-misdiagnosis
- Published: 2026-10-20T18:03:35+00:00
- Read time: 1 min
- Topics: christina applegate, multiple sclerosis, ms misdiagnosis, emmy awards, neuroimmunologist, rheumatoid arthritis, spinal fluid, central nervous system, news, entertainment
## Applegate's MS Diagnosis Reversal
Christina Applegate says she's back at square one after five years believing she had multiple sclerosis.

> Congratulations. You don't have MS
## Symptoms of Worsening Health
Applegate reported tingling in her toes that led to 'insane tingling' from her butt down and leg buckling during filming.

> My knees feel like I have bricks attached to them, heavy and painful
## MS Misdiagnosis Statistics
Up to 1 in 5 patients diagnosed with MS may not actually have MS but a different condition.

> Symptoms of MS are not unique to MS
## MS Symptoms and Progression
MS affects nearly 1 million Americans and can cause vision problems, muscle weakness, and cognitive changes.

> Muscle weakness and pain can affect walking or standing or lead to paralysis
## Applegate's Current Health Status
Applegate requires a wheelchair during filming and walks with a cane since 2021, with severe knee pain and numbness.

> When I put my feet down on the ground when I wake up, it feels as if the floor is made of needles
## Next Steps for Diagnosis
Applegate's doctors are embarking on an online investigation to find the cause of her health issues since 2021.

> It's important to talk to a neuroimmunologist at an academic center to review whether this is autoimmune
## Possible Causes of Symptoms
Rheumatoid arthritis and other autoimmune conditions are being explored as potential causes of Applegate's symptoms.

> There's probably something causing inflammation within her central nervous system
## MS Mimics and Misdiagnosis
Conditions like rheumatoid arthritis, Lyme disease, and syphilis can mimic MS symptoms and lead to misdiagnosis.

> Tingling or blurry vision can occur due to dozens of other diagnoses
## Key takeaway

Christina Applegate's doctors confirmed she doesn't have multiple sclerosis after years of symptoms and misdiagnosis.