# FENIB: Family Disease Found in Death Certificate

> A woman discovered her family's rare genetic dementia through a death certificate, linking three generations of women to FENIB.
- Title: FENIB: Family Disease Found in Death Certificate · Clarín
- Summary: A woman discovered her family's rare genetic dementia through a death certificate, linking three generations of women to FENIB.
- Keywords: fenib, genetic dementia, family disease, death certificate, neuroserpina, serpini1 gene, Clarín
- Source: Clarín — https://clarin.com/estados-unidos/descubrio-certificado-defuncion-nombre-enfermedad-afecto-generaciones-mujeres-familia-fenib-demencia-genetica-rara_0_iOanvs0L9g.html
- Author: Redacción Clarín
- Published: 2026-11-12T17:26:25+00:00
- Read time: 1 min
- Topics: fenib, genetic dementia, family disease, death certificate, neuroserpina, serpini1 gene, news
## Miranda Pappas' family disease
Miranda Pappas grew up knowing her family had a disease but didn't know its name.
## Three generations affected
Her grandmother died at 29, her mother showed symptoms when she was young, and her sister died at 41 after a diagnosis at 26.
## Family's secret disease
For decades, family members referred to the disease as 'eso' without understanding its cause.
## Death certificate clue
Pappas reviewed her grandmother's death certificate, which listed acute coronary thrombosis as the cause of death.
## FENIB identified
Using AI, Pappas found the disease was encephalopathy with neuroserpin inclusions, known as FENIB.
## Family's genetic link
FENIB is a rare genetic dementia caused by mutations in the SERPINI1 gene, leading to neuroserpin accumulation in neurons.
## Key takeaway

Miranda Pappas identified FENIB, a rare genetic dementia affecting three generations of her family, after reviewing her grandmother's death certificate.