# Georgia State University Finds Metabolite Compounds for Ulcerative Colitis

> New compounds from Georgia State University show promise for ulcerative colitis treatment.
- Title: Georgia State University Finds Metabolite Compounds for…
- Summary: New compounds from Georgia State University show promise for ulcerative colitis treatment. Georgia State University researchers identified…
- Keywords: georgia state university, ulcerative colitis, metabolite-inspired compounds, anti-inflammatory, mly2, mly8, m13, phase ii metabolites, inflammatory disease, colitis, startups, business
- Source: Pulse 2.0 — https://pulse2.com/georgia-state-university-metabolite-inspired-compounds-show-promise-for-ulcerative-colitis-drug-discovery
- Author: Amit Chowdhry
- Published: 2026-10-14T21:39:47+00:00
- Read time: 1 min
- Topics: georgia state university, ulcerative colitis, metabolite-inspired compounds, anti-inflammatory, mly2, mly8, m13, phase ii metabolites, inflammatory disease, colitis, startups, business
## New Compounds Show Promise
Georgia State University researchers identified two metabolite-inspired compounds that showed enhanced anti-inflammatory activity in ulcerative colitis models.
## Compounds Improved Disease Measures
MLY2 and MLY8 restored colon length and reduced fecal lipocalin-2 in mouse colitis models.
## Compounds Suppressed Inflammation
MLY2 and MLY8 suppressed inflammatory cytokine production more effectively than M13 in human colon tissue.
## Metabolites as Drug Starting Points
Biologically active phase II metabolites could serve as underused starting points for new anti-inflammatory drugs.

> This work shows that modifying the chemical structure of a biologically active phase II metabolite can be a productive strategy for discovering new anti-inflammatory drug candidates. The findings provide a foundation for follow-up studies, suggesting that biologically active phase II metabolites may represent underutilized scaffolds for medicinal chemistry optimization in inflammatory disease.
## Key takeaway

Georgia State University researchers identified metabolite-inspired compounds that reduce inflammation in ulcerative colitis models.