# Hormone Therapy Boosts GLP-1 Weight Loss for Some Women

> Estrogen may enhance weight loss from GLP-1 drugs for women going through menopause.
- Title: Hormone Therapy Boosts GLP-1 Weight Loss for Some Women
- Summary: Estrogen may enhance weight loss from GLP-1 drugs for women going through menopause. Women using hormone therapy lost 11.6% more weight with GLP-1 drugs like…
- Keywords: menopause, glp-1, ozempic, wegovy, hormone therapy, weight loss, semaglutide, tirzepatide, Hormone, Therapy, Boosts, Weight
- Source: Newsweek — https://newsweek.com/hormone-therapy-linked-women-respond-glp-1-weight-loss-drugs-12651955
- Published: 2026-11-03T10:20:38+00:00
- Read time: 1 min
- Topics: menopause, glp-1, ozempic, wegovy, hormone therapy, weight loss, semaglutide, tirzepatide
## Menopause and Weight Loss
Menopause makes weight loss harder for women, especially as more turn to GLP-1 drugs like Ozempic and Wegovy.
## Study Finds Estrogen Role
A Mayo Clinic Florida study suggests estrogen affects how some women respond to GLP-1 weight loss drugs.
## Semaglutide Group Results
Women on semaglutide lost 11.6% more weight with hormone therapy by 15 months compared to nonusers.
## Tirzepatide Group Results
Hormone therapy users lost slightly more weight early with tirzepatide but differences were not statistically significant later.
## Lead Author Explanation
Dr. Regina Castaneda says estrogen may amplify GLP-1's appetite-suppressing effects through synergy.
## Expert Opinion
Dr. Jessica Duncan says hormone therapy may help weight loss for midlife women but needs more research.
## Key takeaway

Women using hormone therapy lost 11.6% more weight with GLP-1 drugs like Ozempic than those without therapy.