# Monday's best bets across NFL and MLB

> Rams host Giants on Monday Night Football while three MLB teams battle in the final week of the regular season.
- Title: Monday's best bets across NFL and MLB · CBS Sports | Shortify
- Summary: Rams host Giants on Monday Night Football while three MLB teams battle in the final week of the regular season. The Rams are favored to bounce back against…
- Keywords: nfl, mlb, monday night football, rams, giants, blue jays, orioles, tigers, nationals, twins, sports betting, sports
- Source: CBS Sports — https://cbssports.com/betting/news/todays-top-games-to-watch-best-bets-odds-giants-vs-rams-on-mnf-blue-jays-vs-orioles-and-more
- Published: 2026-09-21T19:30:44+00:00
- Read time: 2 min
- Topics: nfl, mlb, monday night football, rams, giants, blue jays, orioles, tigers, nationals, twins, sports betting, sports
## Rams seek rebound after Australia loss
Los Angeles lost 27-7 to San Francisco in Week 1 with star pass rusher Myles Garrett sidelined by a knee injury. The Rams are 6.5-point favorites against the Giants on Monday Night Football.
## Aaron Donald makes season debut
The three-time Defensive Player of the Year is attempting a comeback after retiring following the 2023 season. The 35-year-old will likely receive limited playing time in his first game back.
## Puka Nacua questionable with hip injury
The wide receiver led the NFL last season with 129 receptions but is a game-time decision for Monday. He had five catches for 74 yards in the Rams' Week 1 loss.
## Giants come off dominant Week 1 win
New York defeated Dallas 28-20 with quarterback Jaxson Dart throwing three touchdown passes, two to tight end Isaiah Likely in his Giants debut. The Giants haven't beaten the Rams since 2016.
## Rams dominate recent head-to-head
Los Angeles has won the last four meetings against New York and leads the all-time series 30-17. The Giants' last victory came in 2016.
## Blue Jays chase playoff hopes
Toronto is three games behind Chicago for the third wild card with six games remaining. The reigning AL champions have lost four of their last six games.
## Blue Jays-Orioles projects for high scoring
The AL East rivals have combined for nine or more runs in each of their last nine matchups this season. The SportsLine model projects the Over 7.5 to hit 54% of the time.
## Orioles trail in wild card race
Baltimore hasn't been officially eliminated but trails Chicago by five games with six games remaining after a three-game sweep by Milwaukee. The Orioles are -111 favorites against Toronto.
## Tigers back Tigers to beat Nationals
Detroit is favored at -136 against Washington in a matchup of teams with identical 73-83 records. Both starting pitchers are making their first major-league appearance since 2024.
## Tigers-Nationals projects for plenty of runs
The SportsLine model has the Over 8.5 hitting in more than 62% of simulations. Washington is third in the majors in scoring with 798 runs despite being 10 games under .500.
## Giants home strength favors them vs Twins
San Francisco is 36-39 at Oracle Park but 28-39 on the road. The SportsLine model has the Giants covering the run line 74% of the time with an A grade.
## Twins favored despite road struggles
Minnesota is -122 favorites but just 33-45 on the road and haven't won back-to-back away games since August 6-7. Expert Angelo Magliocca backs the Twins to win.
## Key takeaway

The Rams are favored to bounce back against the Giants, while the Blue Jays and Orioles matchup projects for high scoring.