# NFL Week 3 Upset Alert: Five Favorites at Risk

> Three home underdogs could flip Week 3 NFL favorites with young QB injuries and shaky defenses
- Title: NFL Week 3 Upset Alert: Five Favorites at Risk · CBS Sports
- Summary: Three home underdogs could flip Week 3 NFL favorites with young QB injuries and shaky defenses Rams' Bo Nix and Texans' C.J. Stroud face critical challenges…
- Keywords: nfl, rams, denver broncos, texans, indianapolis colts, los angeles, bo nix, c.j. stroud, jameis winston, jackson dart, giant defense, nfl week 3
- Source: CBS Sports — https://cbssports.com/nfl/news/nfl-week-3-2026-upset-picks
- Published: 2026-09-24T12:10:31+00:00
- Read time: 1 min
- Topics: nfl, rams, denver broncos, texans, indianapolis colts, los angeles, bo nix, c.j. stroud, jameis winston, jackson dart, giant defense, nfl week 3
## Week 2 Predictions Hit
Ravens and Saints delivered upsets last week, with Bengals overcoming Texans as road underdogs
## Falcons' QB Return
Atlanta Falcons return Michael Penix Jr. after two weak weeks, aiming to improve offense with Bijan Robinson and Drake London
## Packers' Struggles
Green Bay Packers rank dead last in rushing and have worst third-down offense in nfl with 19 percent conversion rate
## Panthers vs Browns
Deshaun Watson leads Browns to 23-19 win over Buccaneers, improving his career passer rating to 121.9
## Texans' Defensive Slide
Houston Texans defense dropped from 2nd to 24th in nfl rankings after two weeks of play
## Colts' Defensive Challenge
Indianapolis Colts defense faces pressure from Texans' offensive struggles and potential injury to Nico Collins
## Giants' QB Crisis
Giants' Jaxson Dart injured, Jameis Winston starts with weaker arm strength and higher turnover risk
## Rams' Offensive Boost
Bo Nix averages 9.3 yards per attempt with Jaylen Waddle contributing 138 receiving yards in week 3
## Texans' Offensive Struggles
Houston Texans offense ranks 28th in yards per play with David Montgomery and Woody Marks averaging 2.8 yards per carry
## Giants' Defense Weakness
Giants defense allows 6.5 yards per play, second highest in nfl, with 108.6 passer rating to opponents
## Broncos' Home Advantage
Denver Broncos hold 16-4 record at mile high stadium since bo nix's rookie season
## Rams' Week 3 Challenge
Los Angeles Rams face tough travel schedule after beating giants 28-6 in week 3
## Key takeaway

Rams' Bo Nix and Texans' C.J. Stroud face critical challenges against stronger opponents