# NFL Week 6 Betting Shifts

> 49ers surge as Super Bowl favorite after Rams collapse.
- Title: NFL Week 6 Betting Shifts · New York Post | Shortify
- Summary: 49ers surge as Super Bowl favorite after Rams collapse. The 49ers overtook the Rams as Super Bowl favorites after a 6-0 start, while Eagles odds plummeted…
- Keywords: 49ers, rams, eagles, jalen hurts, nfl, betting, draftkings, news, entertainment, Week, Shifts, New York Post
- Source: New York Post — https://nypost.com/2026/10/20/betting/nfl-week-6-betting-trends-49ers-overtake-rams-eagles-odds-crater
- Published: 2026-10-20T22:21:04+00:00
- Read time: 1 min
- Topics: 49ers, rams, eagles, jalen hurts, nfl, betting, draftkings, news, entertainment
## 49ers become Super Bowl favorites
The 49ers improved to 6-0 with a win over Washington, moving from +680 to +540 at DraftKings Sportsbook.
## Rams fall from Super Bowl favorite
The Rams dropped to 2-4 after a loss to the Cardinals, plummeting from +700 to 12/1 in one week.
## Eagles odds collapse
Philadelphia’s Super Bowl odds fell from 40/1 to 200/1 after Jalen Hurts missed the rest of the season due to blood clots.
## Chiefs underdogs against Seahawks
Kansas City remains undefeated but is now a 2.5-point underdog against the Seahawks, their first time as underdogs.
## Key takeaway

The 49ers overtook the Rams as Super Bowl favorites after a 6-0 start, while Eagles odds plummeted due to Jalen Hurts' injury.