# Oklahoma State vs. Houston: Key Matchups

> Oklahoma State's Week 7 game against Houston hinges on three critical matchups.
- Title: Oklahoma State vs. Houston: Key Matchups | Shortify
- Summary: Oklahoma State's Week 7 game against Houston hinges on three critical matchups. Oklahoma State must overcome Houston's tight end Patrick Overmyer and address…
- Keywords: oklahoma state, houston cougars, drew mestemaker, conner weigman, patrick overmyer, big 12, college football, sports, Oklahoma, State, Houston, Key
- Source: Oklahoma State Cowboys On SI — https://si.com/college/oklahomastate/football/3-matchups-that-will-decide-oklahoma-state-s-week-7-game-against-houston
- Published: 2026-10-16T00:15:00+00:00
- Read time: 1 min
- Topics: oklahoma state, houston cougars, drew mestemaker, conner weigman, patrick overmyer, big 12, college football, sports
## Oklahoma State Cowboys
Oklahoma State Cowboys prepare for biggest game since upset of Oregon Ducks in Week 2.
## Week 7 Game Details
No. 18 Cowboys (4-1, 2-0 in Big 12) face No. 20 Cougars (5-1, 2-1) at 6:30 p.m. on Saturday on Fox.
## Historical Context
Teams met last year in Stillwater with Houston winning 39-17; both teams were going in different directions.
## Quarterback Matchup
Oklahoma State QB Drew Mestemaker vs. Houston QB Conner Weigman: best matchup for Cowboys fans since Week 2 against Oregon.
## Drew Mestemaker
Mestemaker has 1,575 yards, 13 touchdowns, five interceptions; threw for 304 yards against UCF.
## Conner Weigman
Weigman rushed 48 times for 177 yards and six touchdowns; has 1,428 yards for 15 touchdowns and an interception.
## Oklahoma State IOL vs. Houston IDL
Houston's interior defensive lineman De’Marion Thomas ruled out; Myles Parker starts at nose tackle.
## Why This Matters
Houston must learn from UCF's run game strategy to stop Oklahoma State's outside zone runs.
## Patrick Overmyer
Overmyer leads Houston with 33 catches for 400 yards and six touchdowns; caught four touchdowns against Kansas State.
## Linebacker Challenge
Cowboys' best coverage linebacker Ethan Wesloski has a PFF grade of 73.5; must slow down Overmyer.
## Key takeaway

Oklahoma State must overcome Houston's tight end Patrick Overmyer and address defensive gaps to win their Week 7 game.