# Prisco's Week 3 NFL Picks

> Prisco predicts Browns upset and Giants rally in Week 3 NFL picks
- Title: Prisco's Week 3 NFL Picks · CBS Sports | Shortify
- Summary: Prisco predicts Browns upset and Giants rally in Week 3 NFL picks Prisco's Week 3 NFL picks include Browns beating Panthers and Giants rallying behind Jameis…
- Keywords: prisco, browns, panthers, giants, jameis winston, nfl, week 3, picks, upset, chargers, bills, jets
- Source: CBS Sports — https://cbssports.com/nfl/news/priscos-week-3-nfl-picks-browns-upset-panthers-giants-rally-behind-jameis-winston
- Published: 2026-09-27T13:31:00+00:00
- Read time: 1 min
- Topics: prisco, browns, panthers, giants, jameis winston, nfl, week 3, picks, upset, chargers, bills, jets
## Prisco's record
Prisco went 9-7 straight up but 5-10 against the spread in Week 2
## Browns vs Panthers
Prisco picks Browns to beat Panthers 23-20 in an upset

> Browns take it in an upset
## Giants vs Titans
Prisco predicts Giants rally behind Jameis Winston against Titans

> Look for the Giants to rally around him in Dart's absence
## Chargers vs Bills
Bills win 32-23 over Chargers despite Chargers' poor performance

> Bills take it
## Jets vs Lions
Lions win 28-23 with Jets' defense struggling

> The Detroit defense hasn't been good
## Texans vs Colts
Texans beat Colts 31-20 with strong offense

> The Texans get their first victory as the offense comes to life
## Chiefs vs Dolphins
Chiefs win 28-10 over Dolphins with Patrick Mahomes

> Look for a big day by the Chiefs and Patrick Mahomes
## Giants vs Titans
Giants beat Titans 23-14 with Jameis Winston

> He wasn't good in relief Monday night in the loss to the Rams
## Bengals vs Steelers
Bengals win 23-13 over Steelers with strong defense

> The defense had a big day
## Seahawks vs Commanders
Seahawks beat Commanders 24-13 with Marcus Mariota

> With Jayden Daniels out, the Seattle defense will have a much easier day
## Jaguars vs Patriots
Jaguars win 21-16 over Patriots with strong defense

> The New England offense is sputtering
## 49ers vs Cardinals
49ers beat Cardinals 30-17 with Brock Purdy

> I don't see Jacoby Brissett keeping up with Brock Purdy
## Bucs vs Vikings
Bucs beat Vikings 21-20 in defensive upset

> They finally step up
## Key takeaway

Prisco's Week 3 NFL picks include Browns beating Panthers and Giants rallying behind Jameis Winston