# Rams lose to Cardinals in biggest upset of season

> Cardinals stun Rams with 18-16 win in largest upset of NFL season.
- Title: Rams lose to Cardinals in biggest upset of season · CBS Sports
- Summary: Cardinals stun Rams with 18-16 win in largest upset of NFL season. Cardinals beat Rams 18-16 after Rams' offense struggled and special teams faltered.
- Keywords: cardinals, rams, nfl, super bowl, field goal, touchdown, special teams, offensive penalties, defensive penalties, sports, lose, biggest
- Source: CBS Sports — https://cbssports.com/nfl/news/what-went-wrong-rams-vs-cardinals-biggest-upset-of-season
- Published: 2026-10-19T00:22:34+00:00
- Read time: 1 min
- Topics: cardinals, rams, nfl, super bowl, field goal, touchdown, special teams, offensive penalties, defensive penalties, sports
## Cardinals win 18-16
Cardinals capped a wild finish with an 18-16 win over Rams, marking the largest upset of the season.
## Cardinals as underdogs
Arizona entered as 13.5-point underdogs and tied for the largest upset of any game in past five years.
## Rams' offensive struggles
Stafford finished 25-for-33 for 222 yards, two touchdowns and no interceptions, but had a putrid 4.2 yards per attempt.
## Rams' defensive issues
Rams recorded zero sacks against a quarterback who's among the more statuesque in the game.
## Special teams problems
Rams gave up a 40-yard return to Devin Duvernay on the ensuing kickoff after new kicker Blake Grupe got hurt.
## Rams' turnovers
Stafford fumbled twice, including an untouched fumble when trying to wheel out of the pocket.
## Cardinals' strong defense
Cardinals' defense had a major bounce back after allowing 45 points last week to the Lions.
## Rams' record
Rams are 2-4 after entering the season as Super Bowl favorites, tied with Cardinals.
## Key takeaway

Cardinals beat Rams 18-16 after Rams' offense struggled and special teams faltered.