# Rams vs. Giants: Monday Night Football picks

> Super Bowl favorites Rams bounce back against Giants in Week 2 matchup at SoFi Stadium.
- Title: Rams vs. Giants: Monday Night Football picks · CBS Sports
- Summary: Super Bowl favorites Rams bounce back against Giants in Week 2 matchup at SoFi Stadium. The Rams are favored by 6.5 points despite a blowout loss to San…
- Keywords: nfl, rams, giants, monday night football, week 2, sofistadium, betting odds, jaxson dart, cam skattebo, john harbaugh, matthew stafford, sports
- Source: CBS Sports — https://cbssports.com/betting/news/giants-rams-odds-predictions-nfl-picks-best-bets-betting-preview-monday-night-football
- Published: 2026-09-21T22:08:44+00:00
- Read time: 1 min
- Topics: nfl, rams, giants, monday night football, week 2, sofistadium, betting odds, jaxson dart, cam skattebo, john harbaugh, matthew stafford, sports
## Rams stumble in Australia
The defending Super Bowl favorites lost 27-7 to the 49ers in Melbourne despite acquiring Myles Garrett, Trent McDuffie, and Aaron Donald in the offseason.
## Giants start strong under Harbaugh
New head coach John Harbaugh led New York to a 28-20 win over Dallas in Week 1, with Jaxson Dart throwing three touchdowns and Cam Skattebo contributing on the ground.
## Rams favored despite struggles
Los Angeles is still the betting favorite at minus 6.5 points, with the over-under set at 47.5 points for Monday night's matchup at SoFi Stadium.
## Expert pick: Rams -7
SportsLine's Adam Thompson expects Matthew Stafford and the Rams defense to bounce back emphatically, even without Myles Garrett, against a Giants team that faced a weaker Cowboys defense.

> The Rams were embarrassed in Australia by the 49ers. But this team remains the Super Bowl favorite.
## Skattebo set for big rushing game
Props expert Alex Selesnick backs Cam Skattebo to exceed 48.5 rushing yards, noting the Giants running back was impressive in Week 1 and faces a Rams defense weakened by Myles Garrett's absence.

> I think the Giants might be the best team in the NFC East and I was very impressed with New York's offense.
## Key takeaway

The Rams are favored by 6.5 points despite a blowout loss to San Francisco, while the Giants look to start 2-0 under new coach John Harbaugh.