# Seahawks Lose to 49ers in Heartbreaking Week 5

> Seahawks' Week 5 loss to 49ers ends with three winners and three losers.
- Title: Seahawks Lose to 49ers in Heartbreaking Week 5 | Shortify
- Summary: Seahawks' Week 5 loss to 49ers ends with three winners and three losers. Seahawks lost 32-29 to 49ers after key fumbles and missed plays.
- Keywords: seahawks, 49ers, cooper kupp, emmanuel wilson, nehemiah pritchett, george holani, byron murphy ii, sam darnold, jaxon smith-njigba, nfl, week 5, turnovers
- Source: Seattle Seahawks On SI — https://si.com/nfl/seahawks/onsi/3-winners-3-losers-from-seahawks-heartbreaking-week-5-loss-to-49ers
- Published: 2026-10-11T23:49:02+00:00
- Read time: 1 min
- Topics: seahawks, 49ers, cooper kupp, emmanuel wilson, nehemiah pritchett, george holani, byron murphy ii, sam darnold, jaxon smith-njigba, nfl, week 5, turnovers
## Sloppy Game
Seattle Seahawks and San Francisco 49ers combined for seven turnovers.
## Back-and-Forth Contest
The game featured four lead changes with the 49ers winning 32-29.
## Loser: Emanuel Wilson
Emanuel Wilson fumbled the ball away after Seattle had a 10-7 lead.
## Winner: Nehemiah Pritchett
Pritchett picked off Brock Purdy for a 16-yard touchdown.
## Loser: George Holani
Holani fumbled twice in the second quarter after Wilson's fumble.
## Winner: Byron Murphy II
Murphy recorded two sacks in the first half and stopped Kaelon Black for a one-yard loss.
## Loser: Sam Darnold
Darnold threw an interception on third-and-10 and was picked off again.
## Winner: Jaxon Smith-Njigba
Smith-Njigba scored a 16-yard touchdown with an ankle injury.
## Final Score
The 49ers won 32-29 after Cooper Kupp came up just inches short.
## Key Turnovers
Seven turnovers led to 35 points scored on takeaways.
## Week 5 Loss
Seahawks suffered heartbreaking loss in Week 5 game.
## Fumble Impact
Wilson's fumble gave 49ers momentum to take lead 14-10.
## Fourth-Down Play
Cooper Kupp came up just inches short on final fourth-down play.
## Seahawks' Week 5
Seahawks lost 32-29 to 49ers after key fumbles and missed plays.
## Key takeaway

Seahawks lost 32-29 to 49ers after key fumbles and missed plays.