# Week 3 NFL odds, picks and predictions > Buffalo stays unbeaten against LA, while injury questions cloud Giants-Titans and Commanders-Seahawks. - Title: Week 3 NFL odds, picks and predictions · CBS Sports | Shortify - Summary: Buffalo stays unbeaten against LA, while injury questions cloud Giants-Titans and Commanders-Seahawks. Week 3 separates early contenders from pretenders… - Keywords: nfl, week 3, betting odds, picks predictions, buffalo bills, los angeles chargers, new york giants, tennessee titans, seattle seahawks, washington commanders, jaxson dart injury, jayden daniels injury - Source: CBS Sports — https://cbssports.com/betting/news/2026-week-3-nfl-odds-lines-schedule-start-times-picks-predictions-falcons-packers-every-other-game - Published: 2026-09-25T15:46:39+00:00 - Read time: 4 min - Topics: nfl, week 3, betting odds, picks predictions, buffalo bills, los angeles chargers, new york giants, tennessee titans, seattle seahawks, washington commanders, jaxson dart injury, jayden daniels injury ## Buffalo stays unbeaten The Bills opened 2-0 with Josh Allen throwing five touchdowns against Detroit and James Cook rushing for 135 yards in a 41-31 win. They face the 0-2 Chargers as seven-point home favorites. ## Carolina's stunning turnaround The Panthers allowed 59 points in Week 1 but crushed Atlanta 34-3 in Week 2 with Bryce Young throwing three touchdown passes. They travel to Cleveland as three-point road favorites. ## Detroit's heartbreak continues The Lions scored 31 points at Buffalo but lost, with Jared Goff throwing four touchdown passes. They host the Jets at home favored by 6.5 points. ## Houston's offense stalls The Texans produced 374 yards against Cincinnati but scored only six points and failed to reach the end zone in Week 2. They host the Colts as 2.5-point favorites despite offensive struggles. ## Kansas City's perfect start Patrick Mahomes led the Chiefs to a 33-30 overtime win over Indianapolis to improve to 2-0. They face the struggling Dolphins as 10.5-point favorites, the largest spread of Sunday's early games. ## Giants face Titans uncertainty Jaxson Dart suffered a potentially season-ending knee injury, forcing the Giants to turn to Jameis Winston. New York is favored by 2.5 points at home against Tennessee. ## Cincinnati's dominant defense The Bengals held Houston to six points in a 20-6 Week 2 win, with Joe Burrow and Ja'Marr Chase connecting for two touchdowns. They travel to Pittsburgh as 3.5-point favorites. ## Seahawks defense dominates Seattle crushed Arizona 31-7 with Jaxon Smith-Njigba catching three touchdown passes from Drew Lock. The Seahawks hold a strong defense heading into a road matchup against Washington. ## Daniels' elbow injury clouds Commanders Jayden Daniels suffered a dislocated left elbow in a 37-20 loss to Dallas, leaving Marcus Mariota as the backup. Washington faces Seattle's strong defense as 6.5-point underdogs. ## Darnold on track to return Seahawks quarterback Sam Darnold is on a good track to return from a glute injury, per head coach Mike Macdonald. Seattle is favored by 7.5 points on the road against Washington. > on a good track to return ## Patriots' defensive statement New England held Pittsburgh to three points in Week 2 with TreVeyon Henderson scoring on a 39-yard touchdown run. Jacksonville heads home as 2.5-point favorites after stalling offensively. ## San Francisco's hot start The 49ers improved to 2-0 with Brock Purdy completing 20 of 22 passes for 287 yards and two touchdowns against Miami. They face the struggling Cardinals as 8.5-point favorites. ## Arizona's offensive collapse Seattle held the Cardinals to 151 total yards in a 31-7 defeat, with Jacoby Brissett throwing for only 95 yards. Arizona faces a rolling 49ers team in Week 3. ## Minnesota's defensive grind The Vikings beat Chicago 9-3 with Aaron Jones rushing for 105 yards and Brian Flores' defense keeping the Bears out of the end zone. Minnesota travels to Tampa Bay as 2.5-point favorites. ## Dallas' explosive offense Dak Prescott threw four touchdown passes and became Dallas' franchise leader in career passing scores, with CeeDee Lamb adding 153 receiving yards and two touchdowns in a 37-20 win. The Cowboys face Baltimore in Brazil. ## New Orleans' shocking upset The Saints won 24-17 at Baltimore with Tyler Shough completing 27 of 34 passes for 252 yards. They host the 2-0 Raiders as three-point favorites in their home opener. ## Denver's comeback win Bo Nix threw for 288 yards and Jaylen Waddle caught 138 receiving yards as the Broncos erased a 10-point deficit to beat Jacksonville 20-13. Denver hosts the Rams as 2.5-point underdogs. ## Williams' hamstring concern Caleb Williams left Chicago's 9-3 loss to Minnesota in the fourth quarter with a right hamstring injury, forcing Tyson Bagent into the game. The Bears face the unbeaten Eagles on Monday night. ## Philadelphia's survival mode The Eagles escaped Tennessee 24-20 with Jalen Hurts throwing for 264 yards and two touchdowns, and DeVonta Smith catching 10 passes for 117 yards. Philadelphia is favored by 4.5 points at Chicago on Monday. ## Key takeaway Week 3 separates early contenders from pretenders, with unbeaten teams like Buffalo and Cincinnati facing stiffer tests while injured quarterbacks could reshape playoff races.