# Week 4 NFL Odds Model Picks

> Computer model backs Giants and Seahawks to cover spreads.
- Title: Week 4 NFL Odds Model Picks · CBS Sports | Shortify
- Summary: Computer model backs Giants and Seahawks to cover spreads. SportsLine's NFL model predicts Giants cover against Cardinals and Seahawks cover against Chargers…
- Keywords: nfl, seahawks, giants, chargers, sportsline, week 4, betting odds, computer model, football, week 4 nfl, sports, Week
- Source: CBS Sports — https://cbssports.com/betting/news/week-4-2026-nfl-odds-picks-predictions
- Published: 2026-10-03T00:31:22+00:00
- Read time: 1 min
- Topics: nfl, seahawks, giants, chargers, sportsline, week 4, betting odds, computer model, football, week 4 nfl, sports
## Week 4 NFL Odds Board
The Week 4 NFL odds board has 16 games with byes starting Week 5.
## London Game Preview
Colts vs. Commanders in London with Colts favored by 3.5 points.
## Divisional Matchups
Patriots vs. Bills (-7) and Chiefs vs. Raiders (+4.5) on Sunday.
## Saints vs. Falcons
Saints 2.5-point favorites over Falcons for 20th anniversary of Domecoming.
## Model Performance
SportsLine's computer model simulates 10,000 NFL games with 54-43 win rate since 2024.
## Giants Cover Pick
Giants (+2.5, 44.5) cover against Cardinals with Arizona's weak record.
## Seahawks Cover Pick
Seahawks (-7, 42.5) cover against Chargers with 12-game win streak ending.
## Key takeaway

SportsLine's NFL model predicts Giants cover against Cardinals and Seahawks cover against Chargers in Week 4.