# Week 4 NFL Odds Model Picks

> Computer model backs Giants and Seahawks to cover Week 4 spreads.
- Title: Week 4 NFL Odds Model Picks · CBS Sports | Shortify
- Summary: Computer model backs Giants and Seahawks to cover Week 4 spreads. A computer model predicts Giants and Seahawks will cover their Week 4 NFL spreads against…
- Keywords: week 4, nfl, giants, seahawks, cardinals, chargers, spreads, computer model, betting picks, odds, sports, Week
- Source: CBS Sports — https://cbssports.com/betting/news/week-4-2026-nfl-odds-picks-predictions-best-bets
- Published: 2026-10-04T15:34:58+00:00
- Read time: 1 min
- Topics: week 4, nfl, giants, seahawks, cardinals, chargers, spreads, computer model, betting picks, odds, sports
## Week 4 NFL Odds Board
The Week 4 NFL odds board has 16 games with byes starting Week 5.
## London Game Preview
Colts vs. Commanders in London with Colts favored by 4.5 points after Jayden Daniels (elbow) is ruled out.
## Divisional Matchups
Patriots vs. Bills (-7) and Chiefs vs. Raiders (+4.5) are the only divisional contests this week.
## Saints vs. Falcons
Saints are 2-point favorites over Falcons for the 20th anniversary of the 'Domecoming' in New Orleans.
## Computer Model Details
The model simulates every NFL game 10,000 times and has a 54-43 win rate on top-rated picks since 2024.
## Giants Cover Prediction
Giants (+2.5, 44.5) are predicted to cover against Cardinals with Arizona's recent losses and New York's strong time of possession.
## Seahawks Cover Prediction
Seahawks (-7, 42.5) are predicted to cover against Chargers with Justin Herbert's 10 touchdowns and Seattle's win streak.
## Key takeaway

A computer model predicts Giants and Seahawks will cover their Week 4 NFL spreads against Cardinals and Chargers respectively.