Psychiatrists Prescribe GLP-1s for Mental Health

Some psychiatrists use GLP-1 medications to treat depression and anxiety.

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Sep 30, 2026

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Psychiatrists Prescribe GLP-1s for Mental Health

Some psychiatrists use GLP-1 medications to treat depression and anxiety.

In brief

Some psychiatrists use GLP-1 medications to treat depression and anxiety. Psychiatrists are prescribing GLP-1 drugs for mental health benefits after observing improvements in depression. Originally reported by Bon Appétit.

Hilary's Experience

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Hilary, a 39-year-old in California, tried antidepressants for years but felt unimpressed until starting Wegovy for weight loss.

“I didn’t even know it was possible for GLP-1s to have a positive effect on mental illness until it happened to me”

GLP-1s and Mental Health

GLP-1 medications, which help with weight and metabolic health, are being explored for mental health benefits by some psychiatrists.

Research Shows Links

Studies indicate that obesity, high blood sugar, poor gut health, and chronic inflammation often accompany mental illness.

Joanna Buck's Approach

Joanna Buck's Approach

Joanna Buck, a Wisconsin psychiatrist, uses brain-friendly diets as a supplement to traditional therapy for mental health.

Thomas Rutledge's Findings

Thomas Rutledge found a 30% drop in depression severity among 40 patients using GLP-1s within six months.

Potential Benefits

GLP-1s may improve mental health by reducing food obsession and metabolic issues, unlike traditional psychiatric drugs.

Safety Concerns

Some studies warn GLP-1s could increase depression and anxiety risks, but recent reviews found no major concerns.

Future Outlook

Psychiatrists say GLP-1s may become mainstream mental health treatments with more research and monitoring.

The bottom line

Psychiatrists are prescribing GLP-1 drugs for mental health benefits after observing improvements in depression.

Read the original on Bon Appétit

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